A Scalable Random Access Micro-traps Array for Formation, Selective Retrieval and Capturing of Individual Droplets
作者： H. Babahosseini , S. Padmanabhan , T. Misteli , D. L. DeVoe
DOI: 10.1109/EMBC.2019.8857768
关键词:
摘要: Formation, selective retrieval and capturing of individual droplets are key operational capabilities needed for a broad range droplet microfluidic applications. The membrane displacement trap (MDT) element gives robust method uniform discretization controllable manipulation aqueous using an enclosed micro-well covered by elastomer membrane. This capability can be scaled up combining the modular elements with system design that requires minimal number signal inputs. Incorporation MDT pneumatically-controllable multiplexer lead to scalable random access array platform liquid manipulation. Herein, we report development programmable sampling selectively handling 32 10 pneumatic logarithmically scale capacity platform, making it possible manipulate hundreds droplets.
sci-hub.se 参考文章(24)
Si Hyung Jin, Heon-Ho Jeong, Byungjin Lee, Sung Sik Lee, Chang-Soo Lee, A programmable microfluidic static droplet array for droplet generation, transportation, fusion, storage, and retrieval Lab on a Chip. ,vol. 15, pp. 3677- 3686 ,(2015) , 10.1039/C5LC00651A
Amit Gupta, SM Murshed, Ranganathan Kumar, Droplet formation and stability of flows in a microfluidic T-junction Applied Physics Letters. ,vol. 94, pp. 164107- ,(2009) , 10.1063/1.3116089
Todd Thorsen, Richard W. Roberts, Frances H. Arnold, Stephen R. Quake, Dynamic pattern formation in a vesicle-generating microfluidic device. Physical Review Letters. ,vol. 86, pp. 4163- 4166 ,(2001) , 10.1103/PHYSREVLETT.86.4163
Meng Sun, Swastika S. Bithi, Siva A. Vanapalli, Microfluidic static droplet arrays with tuneable gradients in material composition Lab on a Chip. ,vol. 11, pp. 3949- 3952 ,(2011) , 10.1039/C1LC20709A
Shelley L. Anna, Nathalie Bontoux, Howard A. Stone, Formation of dispersions using “flow focusing” in microchannels Applied Physics Letters. ,vol. 82, pp. 364- 366 ,(2003) , 10.1063/1.1537519
Remi Dreyfus, Patrick Tabeling, Herve Willaime, Ordered and disordered patterns in two-phase flows in microchannels. Physical Review Letters. ,vol. 90, pp. 144505- ,(2003) , 10.1103/PHYSREVLETT.90.144505
Wen-Chuan Cheng, Yuan He, An-Yi Chang, Long Que, A microfluidic chip for controlled release of drugs from microcapsules Biomicrofluidics. ,vol. 7, pp. 064102- ,(2013) , 10.1063/1.4829776
Heon-Ho Jeong, Si Hyung Jin, Byung Jin Lee, Taesung Kim, Chang-Soo Lee, Microfluidic static droplet array for analyzing microbial communication on a population gradient Lab on a Chip. ,vol. 15, pp. 889- 899 ,(2015) , 10.1039/C4LC01097C
Levent Yobas, Stefan Martens, Wee-Liat Ong, Nagarajan Ranganathan, High-performance flow-focusing geometry for spontaneous generation of monodispersed droplets Lab on a Chip. ,vol. 6, pp. 1073- 1079 ,(2006) , 10.1039/B602240E
Zhanhui Wang, Min-Cheol Kim, Manuel Marquez, Todd Thorsen, High-density microfluidic arrays for cell cytotoxicity analysis Lab on a Chip. ,vol. 7, pp. 740- 745 ,(2007) , 10.1039/B618734J