Pancreatic endocrine tumors: Immunocytochemical analysis of 125 tumors

摘要: One hundred twenty-five pancreatic endocrine tumors were analyzed by immunocytochemistry using various antisera. Twenty-three of 27 insulinomas, 10 PP-omas (PP: polypeptide) and 15 30 "nonsecreting" benign, whereas 8 13 glucagonomas, 16 24 gastrinomas, 21 VIP-omas (VIP: vasoactive intestinal malignant. As a rule, the hormone secreted tumor causing clinical symptoms could be localized immunocytochemistry. Fifty 95 active found to contain cells immunoreactive peptide(s) not symptoms, 54 shown multicellular. By electron microscopy more than one cell type identified in 12 tumors. Histologically, growth pattern was very variable distribution distinctly patchy. Radioimmunoassay on extracts 20 confirmed presence peptides visualized In 17 22 specimens, groups close contact with ductules parenchyma distant from tumor. Pancreatic probably arise ductular epithelium. They are often multicellular, producing sometimes secreting or hormone-like substance. represent highly complex biologic systems which interrelationship gastrointestinal-pancreatic hormones can studied.