IL-23 Compensates for the Absence of IL-12p70 and Is Essential for the IL-17 Response during Tuberculosis but Is Dispensable for Protection and Antigen-Specific IFN-γ Responses if IL-12p70 Is Available

作者: Shabaana A. Khader , John E. Pearl , Kaori Sakamoto , Leigh Gilmartin , Guy K. Bell

DOI: 10.4049/JIMMUNOL.175.2.788

关键词:

摘要: IL-12p70 induced IFN-gamma is required to control Mycobacterium tuberculosis growth; however, in the absence of IL-12p70, an IL-12p40-dependent pathway mediates induction and initial bacteriostatic activity. IL-23 cytokine containing IL-12p40 subunit covalently bound a p19 that implicated CD4 T cells associated with autoimmunity inflammation. We show p19-deficient mice, mycobacterial growth controlled, there no diminution either number IFN-gamma-producing Ag-specific or local mRNA expression. Conversely, almost total loss both IL-17-producing production IL-17 these mice. The does not alter expression antimycobacterial genes, NO synthase 2 LRG-47, IL-17, which are mediating inflammation, fails substantially affect granulomatous response M. infection lung. Despite this redundancy, provide moderate level protection correlates requirement for IL-12p70-independent Ag-specific, cells. also phenotype naive vitro promotes increase vivo.

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