The Potential Role of Medicinal Plants in Bone Regeneration.

摘要: Background and context Natural healing of bone lesions once incomplete or delayed regeneration represents an important clinical issue plants possess compounds that may enhance healing, avoid losses. Objective The aim this review is to evaluate the potential role medicinal in regenaration. Methods/design This has included relevant studies available MEDLINE-PubMed last three years associated regeneration. descriptors used were "bone plants" plants". Results We selected 59 articles, but only 15 dovetailed study objectives review. These showed have increasing osseointegration their components downregulate biomarkers such as interleukin (IL)-1β, IL-6, IL-8, Tumor Necrosis Factor-α, Metalloproteinase 2, 3. They also upregulate mediators Vascular Endothelial Growth Factor, Transforming-Growing Factor-β1, Bone Morphogenetic Protein-2, osteocalcin, osteopontin, type 1 collagen. control production these cytokines help Plant curcumol, caffeic acid, resveratrol, luteolin, many others be useful health interfere Nuclear Factor-κB Mitogen Activated Protein Kinases, modulate Ca2+ signaling, inflammatory mediator genes, inhibiting osteoclast-mediated resorption. Conclusion Many are effective promoting new pharmaceutical technology pharmacological researchers should performed order establish dose appropriate delivery vehicle administration plant its compounds.