Evaluation of the anti arthritic potential of the Genus Strobilanthus

作者: Tupkari Suresh , Sarpate Rupali

DOI:

关键词:

摘要: Adjuvant induced arthritis is a chronic crippling, skeletonmuscular disorder having nearest approximation to human rheumatoid for which there currently no medicine available effecting permanent cure. Even modern drugs used the amelioration of symptoms, offer only temporary relief and also produce severe side effects. In indigenous system medicine, genus Strobilanthus believed be useful in treatment inflammation arthritis. present study two chemical constituents RVS-A (Lupeol) RVS-C (Doctriacantone) isolated from species namely callosus Nees ixiocephala Benth were evaluated its antiarthritic potential. study, anti-arthritic activity done by Freund's adjuvant model using Prednisolone as standard drug. We various haematological parameters assess effectiveness treatment. The results Fruend’s model, indicated that components (20 mg/kg) both oral route shows percent inhibition 81.71% 84.05% after 21 days respectively, where Standard 5mg/kg showed 95.68% (P<0.01). current investigation concluded, plants Nees, possess significant against justifying therapeutic role arthritic condition.

参考文章(18)
Kānhobā Raṇachoḍadāsa Kīrtikara, The Poisonous Plants of Bombay ,(2003)
R. N. Chopra, I. C. Chopra, S. L. Nayar, Glossary of Indian Medicinal Plants ,(1956)
H. Santapau, The flora of Khandala on the Western Ghats of India Manager of Publications. ,(1953)
Elvira E. Kovač-Bešović, Kemal Durić, Zdenka Kalođera, Emin Sofić, IDENTIFICATION AND ISOLATION OF PHARMACOLOGICALLY ACTIVE TRITERPENES IN Betuale cortex, Betula pendula Roth., Betulaceae Bosnian Journal of Basic Medical Sciences. ,vol. 9, pp. 31- 38 ,(2009) , 10.17305/BJBMS.2009.2853
Joseph Dalton Hooker, The flora of British India ,(2009)
A. Misher, M. J. DiMARTINO, D. T. Walz, ADJUVANT-INDUCED ARTHRITIS IN RATS. II. DRUG EFFECTS ON PHYSIOLOGIC, BIOCHEMICAL AND IMMUNOLOGIC PARAMETERS Journal of Pharmacology and Experimental Therapeutics. ,vol. 178, pp. 223- 231 ,(1971)
Carl M. Pearson, Experimental joint disease Journal of Chronic Diseases. ,vol. 16, pp. 863- 874 ,(1963) , 10.1016/0021-9681(63)90136-X
B. B. NEWBOULD, CHEMOTHERAPY OF ARTHRITIS INDUCED IN RATS BY MYCOBACTERIAL ADJUVANT British journal of pharmacology and chemotherapy. ,vol. 21, pp. 127- 136 ,(1963) , 10.1111/J.1476-5381.1963.TB01508.X
C. A. Ashford, Estimation of Haemoglobin BMJ. ,vol. 1, pp. 163- 163 ,(1942) , 10.1136/BMJ.1.4230.163-B
D. Gilmour, A. J. Sykes, Westergren and Wintrobe Methods of Estimating E.S.R. Compared BMJ. ,vol. 2, pp. 1496- 1497 ,(1951) , 10.1136/BMJ.2.4746.1496