Influence of Core β-1,2-Xylosylation on Glycoprotein Recognition by Murine C-type Lectin Receptors and Its Impact on Dendritic Cell Targeting
作者： Katarzyna Brzezicka , Uwe Vogel , Sonia Serna , Timo Johannssen , Bernd Lepenies
DOI: 10.1021/ACSCHEMBIO.6B00265
关键词:
摘要: Targeting antigens to dendritic cell subsets is a promising strategy enhance the efficacy of vaccines. C-type lectin receptors (CLRs) expressed by cells are particularly attractive candidates since CLR engagement may promote uptake and further stimulate antigen presentation subsequent T activation. While most previous approaches have involved antibody-mediated CLR-targeting, glycan-based targeting has become more in recent years. In present study, we show that small structural glycan modifications markedly influence recognition, targeting, A biantennary N-glycan (G0) its analogous O-2 core xylosylated (XG0) were synthesized, covalently conjugated model ovalbumin, analyzed for binding set murine CLR-Fc fusion proteins using microarray. To evaluate whether differential G0 XG0 CLRs impacted stu...
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