A simple heterocyclic fusion reaction and its application for expeditious syntheses of rutaecarpine and its analogs
作者： Guozheng Huang , Dominika Roos , Patricia Stadtmüller , Michael Decker
DOI: 10.1016/J.TETLET.2014.04.120
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摘要: Abstract In the search for new inhibitors of cholinesterases, a simple heterocyclic fusion reaction isatoic anhydride 8 and 3,4-dihydroisoquinoline 22 was discovered which involves spontaneous dehydrogenation upon heating. Applying reaction, bioactive natural alkaloid rutaecarpine several substituted derivatives out tryptamines anthranilic acids or anhydrides, respectively, can be synthesized without tedious chromatographic purification. This provides fast access to larger amounts compounds with this privileged structure in medicinal chemistry.
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