Rat Hepatocytes in Culture

摘要: The rat liver offers some unique characteristics for the study of cellular functions and tumorigenesis. These include presence a highly differentiated mass cells capable multiplicity chemical processes, as well capacity synchronous regeneration in response to two-thirds partial hepatectomy. Liver tumors have been produced large number carcinogens different structural types. Although much has learned about interactions these with macromolecules, mechanisms by which cause alterations control growth are largely unknown. There several regimens production experimental hepatocellular carcinomas using defined carcinogens. Some employ chronic exposure animal carcinogen (Preussmann, 1978; Wogan, 1976), others limited followed promoting influence (Pitot Sirica, 1980; Forber, 1978, 1979). regenerative provided many investigators over past thirty years tool investigate regulatory involved growth. other adult mammalian tissues that generate dividing cells, such epidermis, bone marrow, reproductive organs.