Organ Function and Quality of Life after Transoral Laser Microsurgery and Adjuvant Radiotherapy for Locally Advanced Laryngeal Cancer
作者： Arno Olthoff , Andreas Ewen , Hendrik Andreas Wolff , Robert Michael Hermann , Hilke Vorwerk
DOI: 10.1007/S00066-009-1967-Y
关键词:
摘要: Transoral laser microsurgery (TLM) and adjuvant radiotherapy are an established therapy regimen for locally advanced laryngeal cancer at our institution. Aim of the present study was to assess value quality life (QoL) data with special regard organ function under consideration treatment efficacy in patients treated larynx-preserving TLM radiotherapy. From 1994 2006, 39 (ten UICC stage III, 29 IVA/B) carcinomas were Data concerning efficacy, QoL (using VHI [Voice Handicap Index], EORTC QLQ-C30 QLQ-H&N35 questionnaires) (respiration, deglutition, voice quality) obtained ten still alive after long-term follow-up. Correlations determined using Spearman rank test. After a median follow-up 80.8 months, 5-year overall survival rate 46.8% locoregional control 76.5%, respectively. The larynx preservation 89.7% all 100% Despite some verifiable problems respiration, speech swallowing, showed subjectively good QoL. is curative option alternative radical surgery. Even if functional deficits unavoidable carcinomas, associated
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