Wnt5a Increases the Glycolytic Rate and the Activity of the Pentose Phosphate Pathway in Cortical Neurons

摘要: In the last few years, several reports have proposed that Wnt signaling is a general metabolic regulator, suggesting role for this pathway in control of flux. critical neuronal functions, but little known about correlation between and energy metabolism. The brain has high demand glucose, which mainly used production. Neurons use highly specific processes require level, such as maintaining electrical potential synthesizing neurotransmitters. Moreover, an important impairment been described all neurodegenerative disorders. Despite key glucose metabolism brain, cellular pathways involved regulating process. We report here Wnt5a induces increase uptake glycolytic rate activity pentose phosphate pathway; effects intracellular generation nitric oxide. Our data suggest stimulates metabolism, effect could be reported neuroprotective