Correlation between macular blood flow and central visual sensitivity in retinitis pigmentosa

摘要: Purpose To investigate the changes in macular blood flow and correlation between those central visual function patients with retinitis pigmentosa (RP). Methods The mean blur rate (MBR), a quantitative blurring index of laser speckle pattern that represents retinal choroidal flow, was measured by flowgraphy. Mean values area were compared 70 RP 28 control subjects. The relationships MBR on one hand and, other, acuity (VA), deviation (MD) averaged sensitivity static perimetry tests (Humphrey Filed Analyzer, 10-2 program) analysed RP. Results Macular decreased to 75% subjects (p < 0.0001, Student's t-test). Spearman's rank testing showed significantly correlated VA (r = −0.261, p = 0.0299), MD (r = 0.438, p = 0.0002) at 4 12 points (r = 0.426 0.442, p = 0.0003 0.0002, respectively). Multivariable-adjusted analysis confirmed independently associated (p = 0.0002) (p < 0.0001 respectively). Conclusions Decreased reduced RP. Although cause–effect remain be elucidated, these findings suggest vascular defects may involved pathogenesis such as vision loss.