Relationship of body mass index with prognosis in breast cancer patients treated with adjuvant radiotherapy and chemotherapy.

作者: Yasemin Benderli Cihan

DOI: 10.7314/APJCP.2014.15.10.4233

关键词:

摘要: Background: The aim of this study was to investigate the relationship body mass index with overall and progression-free survival as well other prognostic factors breast cancer in patients non-metastatic cancer. Materials Methods: We retrospectively reviewed 456 diagnosed Radiation Oncology department Kayseri Teaching Hospital between 2005 2013. investigated prognosis factors. Results: included (447 women 9 men). Mean age at presentation 55.6 years. Of cases, 96.9% underwent modified radical mastectomy 95.0% received chemotherapy, while 82.4% radiotherapy 60.0% were given hormone therapy. Body >25 mg/kg 2 343 cases. Five- 10-years rates 77% 58% whereas 65% 49%, respectively. In univariate analyses, including stage (p=0.046), tumor diameter (p=0.001), lymph node metastasis (p=0.006) (p=0.030) found be significantly associated survival, perinodal involvement (p=0.018). multivariate analysis, (p=0.032; OR: 3.8; 95% CI: 1.1-13), (p<0.000; 0.0; 0.0-0.3), (p=0.005; 0.0-0.5) BMI (p=0.027; 0.02; 0.0-0.8) remained OS. Conclusions: our study, it seen that time shorter underweight obese when compared normal weight patients.

参考文章(25)
Jennifer M. Petrelli, Eugenia E. Calle, Carmen Rodriguez, Michael J. Thun, Body mass index, height, and postmenopausal breast cancer mortality in a prospective cohort of US women Cancer Causes & Control. ,vol. 13, pp. 325- 332 ,(2002) , 10.1023/A:1015288615472
Melinda Protani, Michael Coory, Jennifer H. Martin, Effect of obesity on survival of women with breast cancer: systematic review and meta-analysis Breast Cancer Research and Treatment. ,vol. 123, pp. 627- 635 ,(2010) , 10.1007/S10549-010-0990-0
Jennifer J. Griggs, Melony E. S. Sorbero, Gary H. Lyman, Undertreatment of Obese Women Receiving Breast Cancer Chemotherapy Archives of Internal Medicine. ,vol. 165, pp. 1267- 1273 ,(2005) , 10.1001/ARCHINTE.165.11.1267
So Yeon Ryu, Chun Bae Kim, Chung Mo Nam, Jong Ku Park, Ki Soon Kim, Jong Park, Soo Young Yoo, Kyung Sook Cho, None, Is body mass index the prognostic factor in breast cancer?: a meta-analysis. Journal of Korean Medical Science. ,vol. 16, pp. 610- 614 ,(2001) , 10.3346/JKMS.2001.16.5.610
Foluso O. Ademuyiwa, Adrienne Groman, Tracey O'Connor, Christine Ambrosone, Nancy Watroba, Stephen B. Edge, Impact of Body Mass Index on Clinical Outcomes in Triple-Negative Breast Cancer Cancer. ,vol. 117, pp. 4132- 4140 ,(2011) , 10.1002/CNCR.26019
Olaf E. Damgaard, Maj-Britt Jensen, Niels Kroman, Tove F. Tvedskov, Quantifying the number of lymph nodes identified in one-stage versus two-stage axillary dissection in breast cancer The Breast. ,vol. 22, pp. 44- 46 ,(2013) , 10.1016/J.BREAST.2012.03.009
Afsoon Taghavi, Zeinab Fazeli, Mohsen Vahedi, Ahmad Reza Baghestani, Asma Pourhoseingholi, Farnoosh Barzegar, Mohamad Amin Pourhoseingholi, Increased trend of breast cancer mortality in Iran. Asian Pacific Journal of Cancer Prevention. ,vol. 13, pp. 367- 370 ,(2012) , 10.7314/APJCP.2012.13.1.367
Rebecca Siegel, Deepa Naishadham, Ahmedin Jemal, Cancer Statistics for Hispanics/Latinos, 2012 CA: A Cancer Journal for Clinicians. ,vol. 62, pp. 283- 298 ,(2012) , 10.3322/CAAC.21153
Suleeporn Sangrajrang, Arkom Chaiwerawattana, Pattama Ploysawang, Kanjamad Nooklang, Paphawin Jamsri, Sopittra Somharnwong, Obesity, Diet and Physical Inactivity and Risk of Breast Cancer in Thai Women Asian Pacific Journal of Cancer Prevention. ,vol. 14, pp. 7023- 7027 ,(2013) , 10.7314/APJCP.2013.14.11.7023
Niyati Parekh, Urmila Chandran, Elisa V. Bandera, Obesity in Cancer Survival Annual Review of Nutrition. ,vol. 32, pp. 311- 342 ,(2012) , 10.1146/ANNUREV-NUTR-071811-150713