Melatonin and Ischemic Stroke: Mechanistic Roles and Action

摘要: Stroke is one of the most devastating neurological disabilities and brain's vulnerability towards it proves to be fatal socio-economic loss millions people worldwide. Ischemic stroke remains at center stage it, because its prevalence amongst several other types attacking brain. The various cascades events that have been associated with involve oxidative stress, excitotoxicity, mitochondrial dysfunction, upregulation Ca(2+) level, so forth. Melatonin a neurohormone secreted by pineal extra tissues responsible for physiological processes like sleep mood behaviour. has implicated in diseases antioxidative, antiapoptotic, anti-inflammatory properties. We previously reviewed neuroprotective effect melatonin models brain injury traumatic spinal cord injury. In this review, we put together causes consequence protective role ischemic stroke.