Pharmacokinetic Features of the Antiparasitic Macrocyclic Lactones

摘要: The macrocyclic lactones have pharmacokinetic properties which enhance their use against endo- and ectoparasites in animals man. most consistent physico-chemical feature of the group contributes to kinetic characteristics is high lipid solubility. This appears be necessary for pharmacodynamic action as well common features such large volumes distribution influence body fat composition on disposition. They are used all domestic animal species undoubtedly influenced by anatomical physiological differences these species, however also exert a major distribution, metabolism persistence between breeds individuals. A myriad formulations been developed convenience administration different delivered orally, subcutaneously topically good effect. Lipid based excipients "depot" extend period effective prevention parasite re-infection. Subtle structural changes made lactone molecules reduce central nervous system mammary gland, thus allowing some compounds selamectin (SLM) "toxicity sensitive" collie dog lack P-glycoprotein efflux systems eprinomectin (EPM) dairy cattle with nil-milk withdrawal period. Gender exist pharmacokinetics may associated (fat) or metabolism. Feeding availability bind particulate digestive material parasitism impact kinetics drugs because parasitized altered pathophysiological processes, especially gastro intestinal tract but condition (and deposition) animals. affected coadministration interfere transporters interactions explored possible mechanisms enhancing effectiveness antiparasitics. objective this article provide comprehensive review interpret where that information prove clinically useful.