In vitro toxicity and genotoxicity assessment of disinfection by-products, organic N-chloramines.

摘要: Disinfection by-products (DBPs) are of concern to both water industries and health authorities. Although several classes DBPs have been studied, there regulated safe levels in disinfected for some, a large portion not characterized, need further investigation. Organic N-chloramines group DBPs, which can be formed during common disinfection processes such as chlorination chloramination, but little is known terms their toxicological significance if consumed drinking water. Only few vitro studies using bacterial assays reported some genotoxic potential organic N-chloramines, largely the context inflammatory body rather than exposure through In this study, we investigated 16 produced by model amino acids amines. It was found that within water-relevant micromolar concentration range, four compounds were cytotoxic mammalian cells. A small reduction cellular GSH also observed treatment with these compounds, magnitude account cytotoxicity genotoxicity. The results presented study demonstrate at low concentrations might present water, harmful