Negative Affectivity, Aging, and Depression: Results From the Neurobiology of Late-Life Depression (NBOLD) Study

摘要: Objective Neuroticism is a common yet understudied condition in older adults. We hypothesized that presence of high negativity affectivity (NA), key feature neuroticism, would be associated with different prefrontal cortex (PFC) activity and connectivity patterns depressed never-depressed Methods This baseline cross-sectional analysis cohort study 52 36 Assessments included NA scores from the Type D Scale-14 Montgomery-Asberg Depression Rating Scale scores. All subjects had 3T brain functional magnetic resonance imaging resting scan, neuronal determined by amplitude low-frequency fluctuations (ALFFs) were obtained, state (FC) analyses performed. Analyses covariance conducted on ALFFs FC to examine significant differences between groups. Results In ALFF there clearly comparison groups correlation NA. The two dorsomedial PFC, insula, amygdala, posterior cingulate (PCC). revealed between-group patterns. Significantly higher ventromedial PFC–amygdala was found group than group. Conclusion confirms differential dorsal ventral regions medial PFC individuals neuroticism. Our findings suggest increased rostral may marker resilience depression elderly decreased anterior PCC, amygdala result successful emotion regulation individuals.