Relationship Between Metabolic Syndrome and Bone Health - An Evaluation of Epidemiological Studies and Mechanisms Involved.

作者: Kok-Yong Chin , Sok Kuan Wong , Sophia Ogechi Ekeuku , Kok-Lun Pang

DOI: 10.2147/DMSO.S275560

关键词:

摘要: Metabolic syndrome (MetS) and osteoporosis are two medical problems plaguing the ageing populations worldwide. Though seemingly distinctive to each other, metabolic derangements shown influence bone health. This review summarises relationship between MetS health derived from epidemiological studies explains mechanistic basis of this relationship. The discourse focuses on link mineral density, quantitative sonometric indices, geometry fracture risk in humans. interesting sex-specific trend relationship, probably due factors related body composition hormonal status, is discussed. Mechanistically, component affects distinctly, forming a complex interacting network influencing skeleton. Lastly, effects management, such as pharmacotherapies, exercise bariatric surgery, bone, presented. aims highlight significant proper management with skeletal system mind could prevent cardiovascular complications.

参考文章(153)
R Caudarella, E Rizzoli, F Vescini, C M Francucci, Salt intake, hypertension, and osteoporosis. Journal of Endocrinological Investigation. ,vol. 32, pp. 15- 20 ,(2009)
Ichiro Manabe, Satoshi Nishimura, Ryozo Nagai, Adipose tissue inflammation in obesity and metabolic syndrome. Discovery Medicine. ,vol. 8, pp. 55- 60 ,(2009)
Cong Liu, Dan Wu, Jing-Fan Zhang, Duo Xu, Wan-Feng Xu, Yu Chen, Bing-Yang Liu, Ping Li, Ling Li, Changes in Bone Metabolism in Morbidly Obese Patients After Bariatric Surgery: A Meta-Analysis. Obesity Surgery. ,vol. 26, pp. 91- 97 ,(2016) , 10.1007/S11695-015-1724-5
Haoliang Zhuang, Xu Zhang, Chuntie Zhu, Xiaoshan Tang, Fang Yu, Guang wei Shang, Xiaoxiao Cai, Molecular Mechanisms of PPAR-γ Governing MSC Osteogenic and Adipogenic Differentiation. Current Stem Cell Research & Therapy. ,vol. 11, pp. 255- 264 ,(2016) , 10.2174/1574888X10666150531173309
Noor EMBI, Dennis B. RYLATT, Philip COHEN, Glycogen Synthase Kinase-3 from Rabbit Skeletal Muscle FEBS Journal. ,vol. 107, pp. 519- 527 ,(2005) , 10.1111/J.1432-1033.1980.TB06059.X
Taulant Muka, Katerina Trajanoska, Jessica C. Kiefte-de Jong, Ling Oei, André G Uitterlinden, Albert Hofman, Abbas Dehghan, M. Carola Zillikens, Oscar H. Franco, Fernando Rivadeneira, The Association between Metabolic Syndrome, Bone Mineral Density, Hip Bone Geometry and Fracture Risk: The Rotterdam Study PLOS ONE. ,vol. 10, pp. e0129116- ,(2015) , 10.1371/JOURNAL.PONE.0129116
Nadia Rucci, Molecular biology of bone remodelling. Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases. ,vol. 5, pp. 49- 56 ,(2008)
Wilfredo Oliva-Olivera, Antonio Leiva Gea, Said Lhamyani, Leticia Coín-Aragüez, Juan Alcaide Torres, Maria Rosa Bernal-López, Pedro Pablo García-Luna, Salvador Morales Conde, Sonia Fernández-Veledo, Rajaa El Bekay, Francisco José Tinahones, Differences in the Osteogenic Differentiation Capacity of Omental Adipose-Derived Stem Cells in Obese Patients With and Without Metabolic Syndrome Endocrinology. ,vol. 156, pp. 4492- 4501 ,(2015) , 10.1210/EN.2015-1413
Marta Jonas, Alina Kurylowicz, Zbigniew Bartoszewicz, Wojciech Lisik, Maurycy Jonas, Zbigniew Wierzbicki, Andrzej Chmura, Piotr Pruszczyk, Monika Puzianowska-Kuznicka, Interleukins 6 and 15 Levels Are Higher in Subcutaneous Adipose Tissue, but Obesity Is Associated with Their Increased Content in Visceral Fat Depots International Journal of Molecular Sciences. ,vol. 16, pp. 25817- 25830 ,(2015) , 10.3390/IJMS161025817
Sylvain Marcellini, Juan Pablo Henriquez, Ariana Bertin, Control of osteogenesis by the canonical Wnt and BMP pathways in vivo BioEssays. ,vol. 34, pp. 953- 962 ,(2012) , 10.1002/BIES.201200061