Early Improvement of Functional Mitral Regurgitation in Patients With Idiopathic Dilated Cardiomyopathy

摘要: The aim of the study was to assess clinical and prognostic impact early functional mitral regurgitation (FMR) improvement on outcome patients with idiopathic dilated cardiomyopathy (IDC). prevalence role FMR improvement, particularly at follow-up, in IDC are still unclear. From 1988 2009, we enrolled 470 available data baseline after 6 ± 2 months. According evolution FMR, were classified into 3 groups: stable absent-mild (downgrading from moderate-severe absent-mild), persistence/early development FMR. At baseline, 177 (38%) had Patients significantly better survival rate—free heart transplant respect those (93%, 81%, 66% vs 91%, 64%, 52% 1, 6, 12 years, respectively; p = 0.044). 6-month follow-up multivariate analysis, associated prognosis (hazard ratio 0.78, 95% confidence interval [CI] 0.64 0.96, 0.02); other independent predictors male gender, failure duration, re-evaluation New York Heart Association class left ventricle systolic function. This model provided more accurate risk stratification compared (Net Reclassification Index 80% 12 months 41% 72 months). In conclusion, a large cohort receiving optimal medical treatment, frequent (53%) emerged as favorable factor an incremental short- long-term power evaluation.