Cholesteryl ester transfer protein gene polymorphisms and severity of coronary stenosis

摘要: PURPOSE Cholesteryl ester transfer protein (CETP) gene is involved in the reverse cholesterol transport humans. Thus, it a candidate for studying susceptibility to coronary heart disease (CHD). The goal of current investigation was determine any association between CETP polymorphisms (I405V and TaqIB), severity stenosis, since extent artery narrowing has been considered as primary determinant survival CHD patients. METHODS stenosis estimated by Gensini (GS) Duke Jeopardy (JS) scores 130 men with documented (mean age 61 +/- 10 yr). Genotyping performed polymerase chain reaction restriction fragment length polymorphism analysis. RESULTS allele frequencies both TaqIB I405V were found Hardy-Weinberg equilibrium. Homozygotes I had lower GS compared heterozygotes (IV) homozygotes V [72(95% CI 51-92) vs. 122(95% 88-157) 136 (95% 74-198), P = 0.009, 0.010, respectively]. In addition, differed carriers [86(95% 72-101) 128(95% 102-154), 0.003]. A correlation (r 0.250, 0.005), but not JS. CONCLUSION Homozygosity I405 favours less severe stenosis. Our findings indicate that may have potential importance screening individuals at high risk developing CHD, establishing efficient prevention measures, searching other factors CHD. However, further prospective investigations larger populations are required confirm these findings.