Solid lipid matrix mediated nanoarchitectonics for improved oral bioavailability of drugs.

摘要: Introduction: Solid matrix mediated lipid nanoparticle formulations (LNFs) retain some of the best features ideal drug carriers necessary for improving oral absorption and bioavailability (BA) both hydrophilic hydrophobic drugs. LNFs with solid matrices may be typically categorized into three major types formulations, viz., nanoparticles (SLNs), nanostructured (NLCs) lipid-drug conjugate (LDC-NPs). based are, potentially, most appropriate delivery systems poorly water soluble drugs in need improved solubility, permeability, absorption, or increased BA. In addition, as are able to encapsulate a single on their excellent ability form cores shells. Interestingly, also act devices impart chemical stability various orally administered Areas covered: Aim review is forecast presentation pharmacokinetic characteristics nanocarriers which biocompatible, biodegradable non-toxic carrier efficient Efficient broadly by fact that lipophilic readily lipidic substrates capable permeating across gut epithelium following administration, subsequently delivering moiety interest more efficiently mucosal membrane. This enhances overall BA many facing challenges profile. article specifically focuses biopharmaceutical aspects such nanoformulations possible mechanisms better administration. It briefly reviews methods access efficacy drugs, regulatory interesting lipid-derived commercial concluding remark. Expert opinion: enhance