Scanning and transmission electron microscopy of the cells forming the hepatic sinusoidal wall of rat in acetaminophen and Escherichia coli endotoxin-induced hepatotoxicity.

摘要: Drugs and xenobiotics as well bacterial endotoxins may reach the liver either systematically or after intestinal absorption. Therefore, cells lining sinusoidal wall form last barrier before blood constituents get in contact with parenchymal cells. In this work, ultrastructure of forming was studied acetaminophen Escherichia coli endotoxin treatments. Rats received at a dose 1000 mg/kg body weight by intraperitoneal injection once acute four times 1-week interval chronic treatments, E. 5 Tissue samples were collected for scanning transmission electron microscopy. Swelling endothelial noticed both intoxicated groups narrowing fenestrae, whereas large gaps formed toxicity. Activation Kupffer prominent common feature between toxicity groups. Interestingly, hepatic stellate cell activation evident Large amounts collagen fibers seen surrounding Disse space.