Novel factors modulating human β-cell proliferation.

摘要: β-Cell dysfunction in type 1 and 2 diabetes is accompanied by a progressive loss of β-cells, an understanding the cellular mechanism(s) that regulate β-cell mass will enable approaches to enhance hormone secretion. It becoming increasingly recognized enhancement human proliferation one potential approach restore prevent and/or cure diabetes. While several reports describe factor(s) replication animal models or cell lines, promoting effective continues be challenge field. In this review, we discuss recent studies reporting successful including WS6, IkB kinase EBP1 inhibitor; harmine 5-IT, both DYRK1A inhibitors; GNF7156 GNF4877, GSK-3β osteoprotegrin Denosmab, receptor activator NF-kB (RANK) SerpinB1, protease inhibitor. These provide important examples proteins pathways may prove useful for designing therapeutic strategies counter different forms