Dementia in Parkinson’s Disease

摘要: The subject of dementia in patients with Parkinson’s disease has often been discussed, especially regard to its clinical and neuropathological manifestations, but more recently, as neurochemical data accumulate, on a fundamental biological level. It become traditional begin discussion this the remark that James Parkinson (1817) explicitly excluded intellectual deterioration from picture bears his name. is possible that, since then, life-span increased, permitting longer evolution appearance what might be later symptoms degenerative process. One also imagine had an intuition “something” peculiar about mental status parkinsonian required commentary. In 70 years have followed original definition disease, produced voluminous (approximately 200 articles dealing expressly subject) contradictory, if not polemical, literature.