Cardiopulmonary exercise testing and survival after elective abdominal aortic aneurysm repair

作者: S.W. Grant , G.L. Hickey , N.A. Wisely , E.D. Carlson , R.A. Hartley

DOI: 10.1093/BJA/AEU383

关键词:

摘要: Background Cardiopulmonary exercise testing (CPET) is increasingly used in the preoperative assessment of patients undergoing major surgery. The objective this study was to investigate whether CPET can identify at risk reduced survival after abdominal aortic aneurysm (AAA) repair. Methods Prospectively collected data from consecutive who underwent before elective open or endovascular AAA repair (EVAR) two tertiary vascular centres between January 2007 and October 2012 were analysed. A symptom-limited maximal performed on each patient. Multivariable Cox proportional hazards regression modelling factors associated with survival. Results included 506 a mean age 73.4 (range 44–90). majority (82.6%) men most (64.6%) EVAR. in-hospital mortality 2.6%. median follow-up 26 months. 3-year for zero one sub-threshold value ( V ˙ O 2 AT<10.2 ml kg−1 min−1, peak <15 min−1 E/ C AT>42) 86.4% compared 59.9% three values. Risk independently female sex [hazard ratio (HR)=0.44, 95% confidence interval (CI) 0.22–0.85, P=0.015], diabetes (HR=1.95, CI 1.04–3.69, P=0.039), statins (HR=0.58, 0.38–0.90, P=0.016), haemoglobin g dl−1 (HR=0.84, 0.74–0.95, P=0.006), (HR=1.63, 1.01–2.63, P=0.046), AT>42 (HR=1.68, 1.00–2.80, P=0.049). Conclusions variables are independent predictors cohort 3 years post-procedure. potentially useful adjunct clinical decision-making AAA.

参考文章(37)
A. M. Nugent, M. Riley, J. Megarry, J. MacMahon, R. Lowry, M. J. G. O’Reilly, Cardiopulmonary exercise testing in the pre-operative assessment of patients for repair of abdominal aortic aneurysm. Irish Journal of Medical Science. ,vol. 167, pp. 238- 241 ,(1998) , 10.1007/BF02937421
R. C. F. Sinclair, G. R. Danjoux, V. Goodridge, A. M. Batterham, Determination of the anaerobic threshold in the pre-operative assessment clinic: inter-observer measurement error Anaesthesia. ,vol. 64, pp. 1192- 1195 ,(2009) , 10.1111/J.1365-2044.2009.06074.X
Nicolas Diehm, James F. Benenati, Gary J. Becker, Ramon Quesada, Athanassios I. Tsoukas, Barry T. Katzen, Margaret Kovacs, Anemia is associated with abdominal aortic aneurysm (AAA) size and decreased long-term survival after endovascular AAA repair Journal of Vascular Surgery. ,vol. 46, pp. 676- 681 ,(2007) , 10.1016/J.JVS.2007.06.027
PATRICIA M. GRAMBSCH, TERRY M. THERNEAU, Proportional hazards tests and diagnostics based on weighted residuals Biometrika. ,vol. 81, pp. 515- 526 ,(1994) , 10.1093/BIOMET/81.3.515
Miklos D Kertai, Eric Boersma, Cynthia M Westerhout, Ron van Domburg, Jan Klein, Jeroen J Bax, Hero van Urk, Don Poldermans, Association between long-term statin use and mortality after successful abdominal aortic aneurysm surgery The American Journal of Medicine. ,vol. 116, pp. 96- 103 ,(2004) , 10.1016/J.AMJMED.2003.08.029
A. J. Turley, A. M. Batterham, E. Kothmann, G. Danjoux, S. J. Owen, A. Parry, Reliability of the anaerobic threshold in cardiopulmonary exercise testing of patients with abdominal aortic aneurysms Anaesthesia. ,vol. 64, pp. 9- 13 ,(2009) , 10.1111/J.1365-2044.2008.05690.X
Xing-Guo Sun, James E. Hansen, Nuria Garatachea, Thomas W. Storer, Karlman Wasserman, Ventilatory efficiency during exercise in healthy subjects. American Journal of Respiratory and Critical Care Medicine. ,vol. 166, pp. 1443- 1448 ,(2002) , 10.1164/RCCM.2202033
J. Carlisle, M. Swart, Mid-term survival after abdominal aortic aneurysm surgery predicted by cardiopulmonary exercise testing. British Journal of Surgery. ,vol. 94, pp. 966- 969 ,(2007) , 10.1002/BJS.5734
Camilla Berge, Erik S. Haug, Pål R. Romundstad, Conrad Lange, Hans O. Myhre, Improved long-term survival following infrarenal abdominal aortic aneurysm repair. Scandinavian Cardiovascular Journal. ,vol. 42, pp. 354- 359 ,(2008) , 10.1080/14017430802061656
Lee A. Fleisher, Joshua A. Beckman, Kenneth A. Brown, Hugh Calkins, Elliott L. Chaikof, Kirsten E. Fleischmann, William K. Freeman, James B. Froehlich, Edward K. Kasper, Judy R. Kersten, Barbara Riegel, John F. Robb, Sidney C. Smith, Alice K. Jacobs, Cynthia D. Adams, Jeffrey L. Anderson, Elliott M. Antman, Christopher E. Buller, Mark A. Creager, Steven M. Ettinger, David P. Faxon, Valentin Fuster, Jonathan L. Halperin, Loren F. Hiratzka, Sharon A. Hunt, Bruce W. Lytle, Rick Nishimura, Joseph P. Ornato, Richard L. Page, Barbara Riegel, Lynn G. Tarkington, Clyde W. Yancy, ACC/AHA 2007 Guidelines on Perioperative Cardiovascular Evaluation and Care for Noncardiac Surgery A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery) Journal of the American College of Cardiology. ,vol. 50, ,(2007) , 10.1016/J.JACC.2007.09.003