Altered matrix at the chondro-osseous junction leads to defects in lymphopoiesis

摘要: The collagen X transgenic and null (ColX-Tg/KO) mice have revealed a link between endochondral ossification (EO) hematopoiesis, thus serve as model systems to study hematopoietic niches. altered function in ColX-Tg/KO resulted not only skeletal defects, which included changes growth plate ultrastructure, localization of heparan sulfate proteoglycans (HSPG), reduced trabecular bone, but also B lymphocyte numbers throughout life without associated increases cell apoptosis. Consequently, the exhibited diminished vitro vivo immune responses. Moreover, expression several lymphopoietic cytokines were measured from ColX-KO-derived hypertrophic chondrocyte osteoblast cultures. Together, these data expand current niche by including EO-derived extracellular matrix, for example, X/HSPG network, well chondrocytes osteoblasts signal mediating cells.