Vaccination against multiple HPV types.

摘要: Vaccines against the most common human papillomavirus (HPV) types are currently under development. Epidemiologic data suggest that transmission dynamics of different HPV not independent. Some studies indicate interactions among synergistic, where infection with one type facilitates concurrent or subsequent another type. Other point to antagonistic interference types. Here we develop a mathematical model explore how these may either enhance diminish effectiveness vaccination programs designed reduce prevalence associated cervical cancer. We analyze local stability infection-free and boundary equilibria characterize conditions leading coexistence equilibrium. also illustrate results numerical simulations using realistic parameters. show if mass even included in vaccine.