Failure of low molecular-weight heparin in the prevention of prosthetic mitral valve thrombosis during pregnancy: case report and a review of options for anticoagulation.

摘要: Abstract All mechanical heart valves are thrombogenic and may be associated with thromboembolic complications if anticoagulation is inadequate. This risk increased in pregnancy due to a hypercoagulable state. The ideal regimen pregnant patients prosthetic uncertain. Oral dicoumarol anticoagulants, subcutaneous low molecular-weight heparin, high-dose heparin continuous intravenous each have their own merits demerits. A case presented of patient who had valve thrombosis while receiving required re-do mitral replacement. An analysis also included the options available for anticoagulating this difficult group.