Reparation of Isoniazid and Rifampicin Combinatorial Therapy-Induced Hepatotoxic Effects by Bacopa monnieri.
作者： Sabina Evan Prince , Lavinya B. Udhaya , Priyadharshini S. Sunitha , Geetha Arumugam
DOI: 10.1159/000444856
关键词:
摘要: Drug-induced liver injury is a major challenge in treating tuberculosis with isoniazid (INH) and rifampicin (RIF). This study was aimed at evaluating the protective effects of Bacopamonnieri (Brahmi) against INH RIF-induced hepatotoxicity rat model also to patterns interaction between pregnane X receptor (PXR) chosen active compounds B. monnieri. Hepatotoxicity induced experimental animals by oral administration RIF (50 mg/kg b.w. each/day) for 28 days. The co-administration monnieri (500 b.w./day) INH- rats were studied estimation biochemical analyses. standard hepatoprotective drug silymarin (25 used purpose comparison. In silico docking experiments carried out using PatchDock server results analysed on PyMol molecular viewer. There significant reduction antioxidant status rats. Also, there elevation levels serum function markers able normalise tested parameters. studies reveal PXR bacopaside I. exerts
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