The medicinal chemistry of short lactoferricin-based antibacterial peptides.

摘要: This review discusses antibacterial peptides from the perspective of development into clinically useful chemotherapeutic drugs using short lactoferricin based as examples. The shows how important features for activity can be identified and explored molecular properties a range natural non-natural amino acids. results have been further refined quantitatively "soft-modelling" approach where structural parameters that influence 15-residue model were identified. describes this knowledge is utilised to generate pharmacophores efficacy. These turn out surprisingly small relatively consistent between typical Gram-negative Gram-positive bacteria leading discovery novel class synthetic cationic antimicrobial peptides. compounds are found high against several bacterial strains resistant commercial antibiotics, promising future clinical candidates treatment infections caused by relevant pathogens.