Grading-system-dependent volume effects for late radiation-induced rectal toxicity after curative radiotherapy for prostate cancer.

摘要: Purpose To assess the association between dose distributions in rectum and late Radiation Therapy Oncology Group European Organisation for Research Treatment of Cancer (RTOG/EORTC), Late Effects Normal Tissue SOMA, Common Terminology Criteria Adverse Events (CTCAE) version 3.0 graded rectal toxicity among patients with prostate cancer treated RT. Methods Materials Included study were 124 who received three-dimensional conformal RT for prostate to a total 70 Gy 2-Gy fractions. All completed questionnaires regarding complaints before during long-term follow-up. Grade 2 or worse toxicity, according RTOG/EORTC, LENT CTCAE v3.0 criteria, was analyzed relation volume parameters. Results Dose-volume thresholds (V40 ≥65%, V50 ≥55%, V65 ≥45%, V70 ≥20%, ≤140 cm 3 ), significantly discriminated 0–1 particularly using SOMA systems. The receiving ≥70 (V70) most predictive each grading associations strongest, however, use system. Conclusions Volume effects radiation-induced are present, but their clinical significance depends on system used. This should be taken into account interpretation studies reporting toxicity.