Molecular Mechanisms of Poliovirus Pathogenesis
作者： Akio Nomoto , Satoshi Koike
DOI: 10.1007/978-1-4612-0407-7_6
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摘要: Poliomyelitis, an acute disease of the central nervous system (CNS), is caused by poliovirus. Poliovirus a human enterovirus belonging to Picornaviridae, and classified into three stable serotypes (types 1, 2, 3). strains, except for type 2 virulent infect only primates. The poliovirus infection initiated ingestion virus its primary multiplication in alimentary mucosa. tonsils Peyer’s patches are invaded early course infection, extensive viral occurs these loci. From sites, moves deep cervical mesenteric lymph nodes, then blood. When effective viremia established, spreads CNS, paralytic poliomyelitis as result destruction motor neurons brain spinal cord through lytic replication.
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