Shared and Individual CTL-Defined Antigens on Human Melanoma Cells
作者： T. Wölfel , J. Schneider , M. Hauer , C. Wölfel , W. Herr
DOI: 10.1007/978-3-642-60562-8_2
关键词:
摘要: Cytolytic T Iymphocytes (CTL) have been shown to mediate immune protection and rejection responses in animal tumor models. recognize not intact proteins, but protein-derived peptides presented by HLA molecules on the cell surface. HLA-associated originate from proteins of any cellular location. This allows cells survey organism for alteration occurring intracellularly opens up an enormous variety potential target antigens. For these reasons T-cell-defined antigens are considered as promising candidates targeted immunotherapy.
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