A novel electrospun membrane based on moxifloxacin hydrochloride/poly(vinyl alcohol)/sodium alginate for antibacterial wound dressings in practical application
作者： Ruoqiu Fu , Chenwen Li , Caiping Yu , Hong Xie , Sanjun Shi
DOI: 10.3109/10717544.2014.918676
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摘要: AbstractThis study reports on the performance of sodium alginate (SA)/poly(vinyl alcohol) (PVA)/moxifloxacin hydrochloride (MH) nanofibrous membranes (NFM) capable providing antibacterial agent delivery for wound-dressing applications. The aim this work was to prepare NFM with good permeability properties by employing PVA and SA as carriers. A group 12% PVA/2% solutions blended in various ratios (8:2, 7:3, 6:4, 5:5 4:6, v/v) containing 0.5, 1, 2 or 4 wt% MH were studied electrospinning into nanoscale fibermats. optimum ratio found form smooth fibers uniform fibrous features 6:4. drug release behavior electrospun, effects Pseudomonas aeruginosa Staphylococcus aureus animal wound dressing capabilities also investigated. As much 80% released from electrospun after 10 h incubation at 37 °C. In addition, 0.5 exhibited less activity, whereas those higher concentrati...
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Antonio Francesko, Tzanko Tzanov, Chitin, Chitosan and Derivatives for Wound Healing and Tissue Engineering Advances in Biochemical Engineering \/ Biotechnology. ,vol. 125, pp. 1- 27 ,(2010) , 10.1007/10_2010_93
Tarun Garg, Goutam Rath, Amit K Goyal, None, Comprehensive review on additives of topical dosage forms for drug delivery Drug Delivery. ,vol. 22, pp. 969- 987 ,(2015) , 10.3109/10717544.2013.879355
Somasree Ray, Subham Banerjee, Sabyasachi Maiti, Bibek Laha, Saikat Barik, Biswanath Sa, Uttam Kumar Bhattacharyya, Novel interpenetrating network microspheres of xanthan gum–poly(vinyl alcohol) for the delivery of diclofenac sodium to the intestine—in vitro and in vivo evaluation Drug Delivery. ,vol. 17, pp. 508- 519 ,(2010) , 10.3109/10717544.2010.483256
Ted S. Stashak, Ellis Farstvedt, Ashlee Othic, Update on wound dressings: Indications and best use Clinical Techniques in Equine Practice. ,vol. 3, pp. 148- 163 ,(2004) , 10.1053/J.CTEP.2004.08.006
Hye Sung Kim, Hyuk Sang Yoo, None, MMPs-responsive release of DNA from electrospun nanofibrous matrix for local gene therapy: In vitro and in vivo evaluation Journal of Controlled Release. ,vol. 145, pp. 264- 271 ,(2010) , 10.1016/J.JCONREL.2010.03.006
Ashish Garg, Gopal Rai, Santram Lodhi, Alok P. Jain, Awesh K. Yadav, In-vitro and in-vivo assessment of dextran-appended cellulose acetate phthalate nanoparticles for transdermal delivery of 5-fluorouracil Drug Delivery. ,vol. 23, pp. 1525- 1535 ,(2014) , 10.3109/10717544.2014.978512
Natthan Charernsriwilaiwat, Praneet Opanasopit, Theerasak Rojanarata, Tanasait Ngawhirunpat, Lysozyme-loaded, electrospun chitosan-based nanofiber mats for wound healing. International Journal of Pharmaceutics. ,vol. 427, pp. 379- 384 ,(2012) , 10.1016/J.IJPHARM.2012.02.010
Jian-Wei Lu, Yong-Liang Zhu, Zhao-Xia Guo, Ping Hu, Jian Yu, Electrospinning of sodium alginate with poly(ethylene oxide) Polymer. ,vol. 47, pp. 8026- 8031 ,(2006) , 10.1016/J.POLYMER.2006.09.027
S Schreml, R-M Szeimies, S Karrer, J Heinlin, M Landthaler, P Babilas, The impact of the pH value on skin integrity and cutaneous wound healing Journal of The European Academy of Dermatology and Venereology. ,vol. 24, pp. 373- 378 ,(2010) , 10.1111/J.1468-3083.2009.03413.X
Surya K. Mallapragada, Nikolaos A. Peppas, Paolo Colombo, Crystal dissolution-controlled release systems. II. Metronidazole release from semicrystalline poly(vinyl alcohol) systems Journal of Biomedical Materials Research. ,vol. 36, pp. 125- 130 ,(1997) , 10.1002/(SICI)1097-4636(199707)36:1<125::AID-JBM15>3.0.CO;2-H