A mouse model of chronic bacterial lesions (a cotton trap) for studying oral bacteria - lymphocyte interactions

摘要: We established a mouse model of chronic bacterial infection (cotton trap) to get deeper insight into interactions between immune cells and strains, that are most commonly isolated from periapical processes. have used flow cytometry identify the presence intracellular cytokines activated T collected cotton traps, previously infected with different strains bacteria implanted subcutaneously back mice. provide an evidence anaerobic (Bacteroides sp.) nocardiae more effective in inducing cytotoxic immunity Th1 response compared oral streptococci. Differences against when streptococci probably dependent on some non-specific cell stimulation (e.g. by wall components), nevertheless role specific antigen-dependent mechanism can not be excluded.