Development of a novel postnatal neurobehavioral scale for evaluation of common marmoset monkeys.

摘要: Common marmoset (Callithrix jacchus) monkeys when compared to rhesus macaques (Macaca mullatta) present several advantages for disease modeling, especially transgenic initiatives, as they commonly give birth twins, which increases sample size, have accelerated development and a shorter life span that facilitates the analysis of onset age-related diseases. Yet, no tools are currently available assess neurodevelopment during initial first month life. Here we report creation novel Primate Postnatal Neurobehavioral Assessment Scale (PPNAS-M) was based on scales human monkeys. Twenty-four healthy infants (12 females, 12 males) from families were evaluated. The infant assessments involved 10-minute testing administered at 15 30 days after birth. PPNAS-M consists 41 noninvasive tests grouped into 5 categories: visual orienting, auditory spatial motor responses, righting body strength, temperament tests. Testing these two ages did not affect overall health infants, suggesting is non-invasive tool. Significant maturation demonstrated by increased scores in each five categories postnatal day 30, with developmental patterns unique marmosets. Principal component defined 4 item groups (Orientation, State Control, Motor Maturity Sensory Sensitivity) variables each. Orientation Control factors highly similar other both correlated previous groupings used macaques. Our results indicate useful assessment tool detecting neuromotor, attention, status marmosets it sensitive effects. Further studies validate normal versus early effects perturbations associated prenatal exposures transgenesis warranted.