Growth and Gene Expression Are Predominantly Controlled by Distinct Regions of the Human IL-4 Receptor
作者： John J Ryan , Lisa J McReynolds , Achsah Keegan , Lu-Hai Wang , Evan Garfein
DOI: 10.1016/S1074-7613(00)80677-9
关键词:
摘要: Abstract IL-4 causes hematopoietic cells to proliferate and express a series of genes, including CD23. We examined whether IL-4-mediated growth, as measured by 4PS phosphorylation, gene induction were similarly controlled. Studies M12.4.1 expressing human IL-4R truncation mutants indicated that the region between amino acids 557–657 is necessary for full expression, which correlated with Stat6 DNA binding activity. This was not required phosphorylation. Tyrosine-to-phenylalanine mutations in interval revealed long one tyrosine remained unmutated, CD23 fully induced. When all three tyrosines mutated, receptor unable induce The results indicate growth regulation expression are principally controlled distinct regions IL-4R.
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