Cancer microenvironment and inflammation: role of hyaluronan.
作者： Dragana Nikitovic , Maria Tzardi , Aikaterini Berdiaki , Aristidis Tsatsakis , George N. Tzanakakis
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摘要: The role of inflammation in the development cancer was described as early 19th century. Abundant evidence supports preposition that various cancers are triggered by infection and chronic inflammatory disease whereas, evading immune destruction has been proposed one new “hallmarks cancer.” Changes tumor microenvironment have closely correlated to cancer-mediated inflammation. Hyaluronan (HA), an important ECM component, become recognized active participant inflammatory, angiogenic, fibrotic, promoting processes. This review discusses how HA specific HA-binding proteins participate regulate cancer-related
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