Intravesical resiniferatoxin for refractory detrusor hyperreflexia: a multicenter, blinded, randomized, placebo-controlled trial.
作者： Jang Hwan Kim , David A. Rivas , Patrick J. Shenot , Bruce Green , Michael Kennelly
DOI: 10.1080/10790268.2003.11753706
关键词:
摘要: AbstractObjective: Resiniferatoxin (RTX) is an analogue of capsaicin with more than 1,000 times its potency in desensitizing C-fiber bladder afferent neurons. This study investigated the safety and efficacy intravesical RTX patients refractory detrusor hyperreflexia (DH).Methods: Thirty-six (22 males, 14 females) neurologically impaired (20 spinal cord injury, 7 multiple sclerosis, 9 other neurologic diseases) urodynamically verified DH intractable urinary symptoms despite previous anticholinergic drug use were treated prospectively using dose escalation a double-blind fashion at 4 centers. Patients received single instillation 100 ml placebo (n = 8 patients) or 0.005, 0.025, 0.05 , 0.10 0.2, 0.5, 1.0 fLM each group). A visual analog pain scale (VAPS) (0-10; 10 highest level pain) was used to quantify discomfort application. Treatment effect monitored diary cystometric capacity weeks...
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