Complement and granulocyte activation in two different types of heparinized extracorporeal circuits

摘要: Complement and granulocyte activation were studied in cardiopulmonary bypass circuits completely coated with either end-attached covalent-bonded heparin, the Carmeda BioActive Surface, or Duraflo II bonded combination reduced systemic heparinization (activated clotting time > 250 seconds). The control groups perfused uncoated full heparin dose 480 Altogether 67 patients undergoing elective first-time myocardial revascularization investigated, having extracorporeal perfusion a circuit (n = 17), an identical but equivalent 16). During bypass, C3 products C3b, iC3b, C3c (C3bc) terminal SC5b-9 complemented complex increased markedly all four compared baseline, significantly less two than their groups. Additionally, lower concentration of C3bc was observed group, maximal increase median 28 AU/ml 50 group (p 0.003). Similarly, complement considerably (0.8 AU/ml) levels recognized (2.4 < 0.001). release myeloperoxidase lactoferrin from beginning operation, peak at end bypass. A significant reduction when comparing difference between (Carmeda 228 micrograms/L; 332 p 0.05) marginally significant. For myeloperoxidase, no differences In conclusion, both types heparin-coated lactoferrin, proved to be more effective equipment.