Isolated CNS involvement in eosinophilic granulomatosis with polyangiitis treated with mepolizumab: A case report.
作者： Jangsup Moon , Kon Chu , Sang Kun Lee , Keun Hwa Jung , Woo Jin Lee
DOI: 10.1016/J.JNEUROIM.2021.577551
关键词:
摘要: Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic vasculitis disease involving small-sized vessels. The literature has reported involvement of the central nervous system (CNS) in 5% cases, and isolated CNS extremely rare. Due to its rarity scarcity clinical data, standardized treatment EGPA unclear. Mepolizumab, an anti-interleukin-5 monoclonal antibody, was previously introduced treat longer remission period, more patients showing remission, reduction prednisolone dose those who already taking compared placebo. We describe case EGPA, confirmed by brain biopsy treated mepolizumab, which refractory conventional immunotherapy.
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