Excitement of Clinical Investigation New Basic Mechanisms of Action After Drug Introduction

摘要: Enormous personal satisfaction is frequently derived from experiences resulting systematic clinical investigation. Such are the lessons that have been learned tremendous insight has evolved concerning careful and fundamental study of new therapeutic agents, events after their release for general use. This case exciting gains into cardiac vascular remodeling introduction angiotensin-converting enzyme inhibitors statins. According to editors, an editorial commentary intended “highlight, provide a further perspective, enhance overall significance novel, timely, contributes our understanding physiology, pathophysiology, treatment or prevention hypertension.” To my way thinking, there no better example such article fulfill these criteria than “Modulation Angiotensin II–Mediated Hypertension Cardiac Remodeling by Lectin-Like, Oxidized Low-Density Lipoprotein Receptor-1 Deletion” Hu et al.1 Inherent in this its key words: angiotensin II, remodeling, lectin-like, oxidized low-density lipoprotein receptor-1 (LOX-1) deletion. Moreover, central thesis concept mechanisms cardiovascular “remodeling.” The role …