Ammonium Ion Currents in the Squid Giant Axon

摘要: Voltage-clamp studies on intact and internally perfused squid giant axons demonstrate that ammonium can substitute partially for either sodium or potassium. Ammonium carries the early transient current with 0.3 times permeability of it delayed potassium permeability. The conductance changes observed in voltage clamp show approximately same time course solutions as normal physiological solutions. These ion permeabilities account known effects nerve excitability. Experiments drugs tetrodotoxin (TTX) tetraethyl chloride (TEA) these molecules block late components selectively, even when both are carried by ion, ammonium.