Prolongation of life in an experimental model of aging in Drosophila melanogaster.
作者： R.G. Jordens , M.D. Berry , C. Gillott , A.A. Boulton
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摘要: (R)-Deprenyl, the archetypical monoamine oxidase-B inhibitor, has been shown to increase life-span in a number of species. Although many theories for this effect have suggested, example, an superoxide dismutase (SOD) activity, mechanism action yet be elucidated. To investigate phenomenon, we examined effects (R)-deprenyl, and some aliphatic propargylamines, experimental aging model Drosophila melanogaster. Both wild-type Oregon-R type flies, as well SOD knock-out mutant strain were used. Flies obtained from series paired mates divided equally among treatment groups. In all studies, flies treated duration life following adult emergence. The consists substitution sucrose with galactose regular food media flies. Initial experiments confirmed that such resulted significant (p < 0.01, Breslow test) reduction mean maximal not due nutrient deprivation. Inclusion (R)-deprenyl propargylamines media, at average daily doses range 0.5-1 ng/fly/day, led galactose-treated, but control This was seen both
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