Mesenchymal Stem Cells Shift Mitochondrial Dynamics and Enhance Oxidative Phosphorylation in Recipient Cells.

摘要: Mesenchymal stem cells (MSCs) are the most commonly used in tissue engineering and regenerative medicine. MSCs can promote host repair through several different mechanisms including donor cell engraftment, release of signaling factors, transfer healthy organelles to host. In present study, we examine specific impacts on mitochondrial morphology function tissues. Employing vitro culture inherited disease an vivo animal experimental model low-grade inflammation (high fat feeding), show human-derived alter function. MSC co-culture with skin fibroblasts from patients rescued aberrant a fission state more fused appearance indicating effect network formation. experiments confirmed abundance oxygen consumption rates were elevated tissues following treatment. Furthermore, microarray profiling identified 226 genes differential expression liver animals treated MSC, cellular signaling, actin cytoskeleton regulation as key upregulated processes. Collectively, our data indicate that therapy rescues impaired morphology, enhances metabolic capacity, induces widespread gene shifting. These results highlight potential modulate mitochondria both pathological states.