Alterations in Insulin Levels in Adults with Prenatal Alcohol Exposure.

摘要: OBJECTIVE Evidence suggests that prenatal alcohol exposure (PAE) may adversely impact insulin production and signaling but there is limited information on the range of these effects their future health consequences. METHOD A prospective cohort predominantly African-American individuals identified while in utero followed into adulthood were used to evaluate differences various indicators diabetes, including fasting plasma glucose, hemoglobin A1c (HbA1c), levels. The homeostatic model assessment resistance (HOMA-IR) was also computed. Body mass index (BMI) calculated normal defined as < 25 kg/m2 . Participants categorized as having PAE (n = 39) if mothers drank at least 1 ounce absolute per week or more during 1st trimester pregnancy Controls (n = 22) reported abstaining from consumption pregnancy. RESULTS Mean age sample 36.0 ± 1.5 years. Indices glucose metabolism, levels, did not vary by group status levels HOMA-IR values varied BMI level. with a had lower than Controls. However, subjects, steeper increase relative Control subjects. cluster 5 cases low 4 severe cognitive impairment. CONCLUSIONS bidirectional level associated indicate differential rates diabetes disease brain peripheral areas involved signaling. These alterations contribute metabolic risk PAE.