Potencies and stereoselectivities of enantiomers of huperzine A for inhibition of rat cortical acetylcholinesterase.
作者： Michael McKinney , Jacqueline H. Miller , Fumio Yamada , Werner Tuckmantel , Alan P. Kozikowski
DOI: 10.1016/0014-2999(91)90730-E
关键词:
摘要: The stereoselectivities and mechanisms of the inhibition rat cortical acetylcholinesterase by enantiomers huperzine A were determined. (-)-Huperzine was more potent enantiomer with a Ki value 8 nM. (+)-Huperzine inhibited enzyme 38-fold less potently 300 Racemic about two-fold than active isomer, (-)-huperzine A. mechanism for all three drugs mixed linear competitive type.
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