Mechanisms of disease: Helicobacter pylori virulence factors

作者: Yoshio Yamaoka

DOI: 10.1038/NRGASTRO.2010.154

关键词:

摘要: Helicobacter pylori has an essential role in the development of various gastroduodenal diseases, but only a small proportion people infected with H. develop these diseases. In this Review, Yoshio Yamaoka discusses current knowledge virulence factors CagA, VacA, OipA and DupA. particular, he considers how contribute to differing geographic gastric cancer disease patterns both duodenal ulcer.

参考文章(119)
Nawfal R. Hussein, Richard H. Argent, Christian K. Marx, Sapna R. Patel, Karen Robinson, John C. Atherton, Helicobacter pylori dupA Is Polymorphic, and Its Active Form Induces Proinflammatory Cytokine Secretion by Mononuclear Cells The Journal of Infectious Diseases. ,vol. 202, pp. 261- 269 ,(2010) , 10.1086/653587
Hoda M. Malaty, Epidemiology of Helicobacter pylori infection Best Practice & Research in Clinical Gastroenterology. ,vol. 21, pp. 205- 214 ,(2007) , 10.1016/J.BPG.2006.10.005
Yoshihiro Hirata, Ayako Yanai, Wataru Shibata, Yuzo Mitsuno, Shin Maeda, Keiji Ogura, Haruhiko Yoshida, Takao Kawabe, Masao Omata, Functional variability of cagA gene in Japanese isolates of Helicobacter pylori Gene. ,vol. 343, pp. 165- 172 ,(2004) , 10.1016/J.GENE.2004.08.026
Shumei Ren, Hideaki Higashi, Huaisheng Lu, Takeshi Azuma, Masanori Hatakeyama, Structural Basis and Functional Consequence of Helicobacter pylori CagA Multimerization in Cells Journal of Biological Chemistry. ,vol. 281, pp. 32344- 32352 ,(2006) , 10.1074/JBC.M606172200
Y. Moodley, B. Linz, Y. Yamaoka, H. M. Windsor, S. Breurec, J.-Y. Wu, A. Maady, S. Bernhoft, J.-M. Thiberge, S. Phuanukoonnon, G. Jobb, P. Siba, D. Y. Graham, B. J. Marshall, M. Achtman, The Peopling of the Pacific from a Bacterial Perspective Science. ,vol. 323, pp. 527- 530 ,(2009) , 10.1126/SCIENCE.1166083
S. Censini, C. Lange, Z. Xiang, J. E. Crabtree, P. Ghiara, M. Borodovsky, R. Rappuoli, A. Covacci, cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 14648- 14653 ,(1996) , 10.1073/PNAS.93.25.14648
M Poppe, S M Feller, G Römer, S Wessler, Phosphorylation of Helicobacter pylori CagA by c-Abl leads to cell motility. Oncogene. ,vol. 26, pp. 3462- 3472 ,(2007) , 10.1038/SJ.ONC.1210139
N. R. Hussein, M. Mohammadi, Y. Talebkhan, M. Doraghi, D. P. Letley, M. K. Muhammad, R. H. Argent, J. C. Atherton, Differences in Virulence Markers between Helicobacter pylori Strains from Iraq and Those from Iran: Potential Importance of Regional Differences in H. pylori-Associated Disease Journal of Clinical Microbiology. ,vol. 46, pp. 1774- 1779 ,(2008) , 10.1128/JCM.01737-07
Ryouhei Tsutsumi, Hideaki Higashi, Megumi Higuchi, Masato Okada, Masanori Hatakeyama, Attenuation of Helicobacter pylori CagA·SHP-2 Signaling by Interaction between CagA and C-terminal Src Kinase Journal of Biological Chemistry. ,vol. 278, pp. 3664- 3670 ,(2003) , 10.1074/JBC.M208155200
Y. YAMAOKA, M. S. OSATO, A. R. SEPULVEDA, O. GUTIERREZ, N. FIGURA, J. G. KIM, T. KODAMA, K. KASHIMA, D. Y. GRAHAM, Molecular epidemiology of Helicobacter pylori: Separation of H. pylori from East Asian and non-Asian countries Epidemiology and Infection. ,vol. 124, pp. 91- 96 ,(2000) , 10.1017/S0950268899003209