Skeletal Muscle Force and Functional Exercise Tolerance Before and After Lung Transplantation: A Cohort Study

作者: G. Maury , D. Langer , G. Verleden , L. Dupont , R. Gosselink

DOI: 10.1111/J.1600-6143.2008.02209.X

关键词:

摘要: We investigated the impact of lung transplantation and outpatient pulmonary rehabilitation after on skeletal muscle function exercise tolerance. Skeletal force (Quadriceps force, QF), tolerance (six minute walking distance, 6MWD) were assessed in 36 patients before transplantation. Seventeen male 19 female (age 57 +/- 4) showed weakness A further 32 21% reduction was seen 1.2 (interquartile range 0.9 to 2.0) months LTX. The number days intensive care unit significantly related observed deterioration At this time point 6MWD comparable pre-LTX. Rehabilitation started 37 (IQR 29 61) QF improved (140 91 m, 35 48%, respectively; p < 0.05) with rehabilitation. remained below pre-LTX values. evolution subsequent less compared subjects. conclude that strength deteriorates transplantation, particularly long ICU stay. Outpatient is feasible leads recovery function. In recipients.

参考文章(39)
G Volland, M Dowe, V Mathiowetz, N Kashman, K Weber, S Rogers, Grip and pinch strength: normative data for adults. Archives of Physical Medicine and Rehabilitation. ,vol. 66, pp. 69- 74 ,(1985)
MARTIN SCHWAIBLMAIR, HERMANN REICHENSPURNER, CHRISTIAN MÜLLER, JOSEF BRIEGEL, HEINER FÜRST, JÜRGEN GROH, BRUNO REICHART, CLAUS VOGELMEIER, Cardiopulmonary exercise testing before and after lung and heart-lung transplantation. American Journal of Respiratory and Critical Care Medicine. ,vol. 159, pp. 1277- 1283 ,(1999) , 10.1164/AJRCCM.159.4.9805113
Janet R. Maurer, Adaani E. Frost, Marc Estenne, Timothy Higenbottam, Allan R. Glanville, International guidelines for the selection of lung transplant candidates Transplantation. ,vol. 66, pp. 951- 956 ,(1998) , 10.1097/00007890-199810150-00033
P. N. Sambrook, P. J. Kelly, D. Fontana, T. Nguyen, A. Keogh, P. Macdonald, P. Spratt, J. Freund, J. A. Eisman, Mechanisms of rapid bone loss following cardiac transplantation. Osteoporosis International. ,vol. 4, pp. 273- 276 ,(1994) , 10.1007/BF01623351
A B Evans, A J Al-Himyary, M I Hrovat, P Pappagianopoulos, J C Wain, L C Ginns, D M Systrom, Abnormal skeletal muscle oxidative capacity after lung transplantation by 31P-MRS. American Journal of Respiratory and Critical Care Medicine. ,vol. 155, pp. 615- 621 ,(1997) , 10.1164/AJRCCM.155.2.9032203
Jonathan B. Orens, Frank S. Becker, Joseph P. Lynch III, Paul J. Christensen, G. Michael Deeb, Fernando J. Martinez, Cardiopulmonary Exercise Testing Following Allogeneic Lung Transplantation for Different Underlying Disease States Chest. ,vol. 107, pp. 144- 149 ,(1995) , 10.1378/CHEST.107.1.144
Charlotte Keller, Ylva Hellsten, Adam Steensberg, Bente Klarlund Pedersen, Differential regulation of IL-6 and TNF-α via calcineurin in human skeletal muscle cells Cytokine. ,vol. 36, pp. 141- 147 ,(2006) , 10.1016/J.CYTO.2006.10.014
Peter Hespel, Bert Op't Eijnde, Marc Van Leemputte, Birgitte Ursø, Paul L. Greenhaff, Valery Labarque, Steven Dymarkowski, Paul Van Hecke, Erik A. Richter, Oral creatine supplementation facilitates the rehabilitation of disuse atrophy and alters the expression of muscle myogenic factors in humans. The Journal of Physiology. ,vol. 536, pp. 625- 633 ,(2001) , 10.1111/J.1469-7793.2001.0625C.XD
Matthew J. Mitchell, Maher A. Baz, Michael N. Fulton, Clem F. Lisor, Randy W. Braith, Resistance training prevents vertebral osteoporosis in lung transplant recipients. Transplantation. ,vol. 76, pp. 557- 562 ,(2003) , 10.1097/01.TP.0000076471.25132.52
Joffrey Zoll, Benoit N’Guessan, Florence Ribera, Eliane Lampert, Dominique Fortin, Vladimir Veksler, Xavier Bigard, Bernard Geny, Jean Lonsdorfer, Renée Ventura-Clapier, Bertrand Mettauer, Preserved response of mitochondrial function to short-term endurance training in skeletal muscle of heart transplant recipients. Journal of the American College of Cardiology. ,vol. 42, pp. 126- 132 ,(2003) , 10.1016/S0735-1097(03)00499-6