Novel targets for natural killer/T-cell lymphoma immunotherapy.

摘要: Extranodal natural killer/T-cell lymphoma, nasal type (NKTL) is a rare but highly aggressive Epstein-Barr virus-related malignancy, which mainly occurs in nasopharyngeal and nasal/paranasal areas. In addition to its high prevalence Asian, Central American South populations, incidence rate has been gradually increasing Western countries. The current mainstay of treatment combination multiple chemotherapies irradiation. Although chemoradiotherapy can cure NKTL, it often causes severe fatal adverse events. Because growing body evidence suggests that immunotherapy effective against hematological malignancies, this could provide an alternative for NKTL. review, we focus on how recent findings be used develop efficient immunotherapies