Absorption and disposition of furosemide in congestive heart failure

摘要: Changes in response to furosemide and other diuretics patients with congestive heart failure (CHF) could occur because of disease-induced changes absorption the drug or disposition which affect its access site action. A difference was not found bioavailability forosemide CHF compared normal volunteers, 31 +/- 12 vs. 38 20% (mean sd), respectively. Both groups showed considerable interindividual variability, though serial analyses within individuals revealed consistency. Amounts delivered into urine after an intravenous dose correlated significantly that oral implying variability is caused primarily by either group. Overall, kinetics did differ between groups. Because heterogeneity renal cardiac function among patients, we were able demonstrate correlations plasma clearance function; turn, left ventricular ejection fraction. Consequently, some had disposition, but, for most part, differences abnormal responses to, rather than changed handling diuretic.